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P000142

Understanding Population Genetics

This course in population genetics is intended for PhD students interested in genetic variation, evolutionary processes, and applications in plant breeding or evolutionary biology. The focus is on deepening the understanding of central theoretical processes in population genetics. Particular emphasis is placed on explaining and deriving fundamental models, as well as building intuitive and mathematical understanding.


The course is partly based on the book Understanding Population Genetics (written by Torbjörn Säll and Bengt Olle Bengtsson), but will be adapted to the participants’ backgrounds and needs.


The course is aimed at PhD students in plant breeding, genetics, evolutionary biology, or related fields, with a particular focus on participants with plant-related research projects. The course is open to PhD students at SLU, Lund University, and other universities, space permitting.


Syllabus and other information


Syllabus

P000142 Understanding Population Genetics, 3.0 Credits

Subjects

Education cycle

Postgraduate level

Grading scale

Pass / Failed

Prior knowledge

- Basic knowledge of genetics.
- Some familiarity with probability theory and/or statistics.
- An open attitude towards working with mathematical models and theoretical reasoning.

Before the course, participants will receive preparatory material with recommended literature and example exercises. The aim is to ensure a common minimum level at the start of the course.

Objectives

After completing the course, participants are expected to be able to:

  • Describe and explain fundamental concepts and models in population genetics, such as Hardy-Weinberg equilibrium, genetic drift, mutation, migration, and selection.
  • Derive and interpret key results and relationships in classical and molecular population genetics.
  • Apply population genetic principles to understand real biological systems.
  • Critically review and discuss research literature in population genetics.
  • Reflect on the strengths, limitations, and assumptions of common population genetic models.

Content

  • Introduction to basic models of population genetics
  • Hardy-Weinberg principle and deviations
  • Genetic drift and effective population size
  • Mutation and mutation-drift balance
  • Migration and genetic structure (F-statistics)
  • Natural selection, models, and equilibria
  • Linkage disequilibrium and linkage analysis
  • Exercises in derivations and practical problem-solving

Teaching methods

  • Lectures covering models, proofs, and derivations
  • Instructor-led exercises and group discussions
  • Reflection assignments
  • Optional take-home exam or written summary of a selected model or article

Formats and requirements for examination

To pass the course, the following are required:

  • Active participation in lectures and exercises (at least 80% attendance)
  • Submission of a short written reflection or take-home exam within two weeks after the course ends

Additional information

Course Literature

Säll, T. & Bengtsson, B. O. (2017). Understanding Population Genetics. Supplementary articles and exercises will be provided at the start of the course.

Course leaders

Professor Torbjörn Säll, Lund University, Docent Therése Bengtsson and Docent Cecilia Hammenhag, SLU.

Language

The course will be given in English. Discussions can be held in Swedish if all participants agree.