RNAi: A new way to fight forest diseases

RNAi is a biological process where double-stranded RNA targets and silences specific genes. This mechanism can be harnessed to combat forest fungal diseases sustainably. In a new review article Ramesh Vetukuri, together with colleagues from Czech Republic evaluates the feasibility of RNAi bio-fungicides against forest pathogen. They did this by delving into the accessible delivery methods, environmental persistence, regulatory aspects, cost-effectiveness, community acceptance, and plausible future of RNAi-based forest protection products.

– By using RNAi-based biofungicides, we can selectively target fungal pathogens while sparing non-target species. This precision minimizes ecological disruption and offers a more environmentally friendly alternative to conventional fungicides, says Ramesh Vetukuri, one of the researchers behind the study.

A promising tool to manage fungal pathogens

One of the strengths of RNAi lies in its ability to leverage genomic data from fungal outbreaks, enabling the development of species-specific treatments. Moreover, advancements in delivery methods, such as nanoparticle carriers or sprayable formulations, make RNAi applications increasingly practical in forest environments.

Still, challenges like understanding how long RNAi stays in the environment and its impact on other species need more research.

– With more development, this method could help keep forests healthy for future generations, concludes Amit Roy, another researcher behind the study.