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Paul Löffler

Paul Löffler

Research

I investigate the proliferation and transmission of antibiotic resistance resulting from transformation products of antimicrobial chemicals in aquatic environments. Therefore, I assess selected transformation products in different freshwater microcosms and try to establish and validate a robust analytical scheme for detecting and isolating the major products using LC-Orbitrap-MS. This method is further used to investigate the impact of antimicrobial transformation products on the aquatic resistome (expression of antibiotic resistent genes ARGs and mobile genetic elements MGEs using high throughput-qPCR) in different freshwater microcosms . Lastly, I  aim to investigate spatial profiles of transformation products, parent compounds, ARGs, MGes and microbial communities in freshwaters across (intern)ational locations.

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Keywords: transformation products, antibiotic resistance, LC-MS/MS, HT-qPCR, recipient waters

Background

M. Sc. in Ecotoxicology at the University of Koblenz-Landau (Germany). Thesis title: "Quantitative screening for polyethylene, polypropylene and polypropylene debris in mulched agricultural soils using pyrolysis-gas chromatography/mass spectrometry"

B. Sc. in Chemistry at University of Stuttgart (Germany). Thesis title: "Synthesis of amino acid-based crosslinkers for hydrogels"

Selected publications

Löffler, P. (2021) Review: Vaccine Myth-Buster - Cleaning Up With Prejudice and Dangerous Misinformation. Front. Immunol. doi: 10.3389/fimmu.2021.663280

Haalck, I., Löffler, P., Baduel, C., Wiberg, K., Ahrens, L., Lai, F.Y. (2021) Mining chemical information in Swedish wastewaters for simultaneous assessment of population consumption, treatment efficiency and environmental discharge of illicit drugs. Sci. Rep. 11, 13510. doi: 10.1038/s41598-021-92915-4

Steinmetz, Z., Löffler, P., Eichhöfer, S., David, J., Muñoz, K., Schaumann, G.E. (2021) Are agricultural plastic covers a source of plastic debris in soil? A first screening study [preprint] doi: 10.5194/soil-2021-70