Michael Palmer

I am post doctoral researcher in translational research on how tissues and cells interact with biomaterials. My research supervisor is Odd Höglund, and I work in the department of clinical sciences helping develop cadaver tissue, live animal, and biomechanical models to evaluate new ways to treat bone and joint injuries (e.g. using a tissue adhesive for arthrodesis, or bioceramics for spinal fusion). I am currently funded via a U-Share grant (Ushare project), which aims to create/strengthen collaboration between Uppsala University and SLU.

While I am not currently teaching, I often assist with biomaterials and molecular biology related coursework.

My research is focused on biological assays (cell studies), material synthesis, and biomechanical testing of tissues and materials. I am particularly interested in how cells and tissues respond to different materials, including immunomodulation, MSC recruitment and differentiation, gene expression (RNAseq), new bone growth (histology), and in how new materials can be designed to improve healing.

I obtained my bachelor and master degree from the USA (biology and biomedical engineering), and PhD in material science/engineering from Uppsala University in 2017. I have also worked in industry for 5 years (USA). I remained at the same laboratory at Uppsala University, working under professor Håkan Engqvist, as a post doctoral and researcher as part of an SSF project (RMA15-0110, Syntes och processning av aktive kalciumfosfatcement) on developing and characterizing calcium phosphate biomaterials.

Kateřina Vrchovecká (03/2020 – 04/2020, and 09/2020 – 12/2020) PhD erasmus exchange project: Testing properties of bone adhesive on dental cells (MDPC23). (Manuscript in preparation)

Joseph Lazraq (06/2019 – 07/2019) bachelor research project: Mechanical and degradation study of tissue adhesive in simulated body fluids. (Publication)

Roger Pujols (09/2018 – 06/2019) master thesis: Identification of additives to control curing of a bone tissue adhesive. (Publication)

Alejandra Pichardo (09/2018 – 12/2018) master internship project: Identification of additives improve osteoinductivity of cements.

Xiuwen Liu (03/2018 – 06/2018 and 02/2018 – 04/2019 ) master thesis: Optimization of a bone tissue adhesive towards soft tissues. (Publication)

Sladkova, M., Palmer, M., Öhman, C., López, A., Wang, H., Engqvist, H., Maria de Peppo, G. A Biomimetic Engineered Human Bone Platform that Reproduces Osseointegration of Titanium and Stainless Steel Implants. Submitted to Scientific reports. Scientific Reports, Nature, 2020, 10, 22154. Doi: 10.1038/s41598-020-78416-w.

Omar, O., Engstrand, T., Linder, L., Åberg, J., Shah, F., Palmquist, A., Birgersson, U., Elgali, I., Pujari-Palmer, M., Engqvist, H., Thomsen, P. In situ bone regeneration of large cranial defects using synthetic ceramic implants with a tailored composition and design. Proceedings of the national academy of sciences (P.N.A.S.), 2020, 117:43,  26660-26671. Doi: 10.1073/pnas.2007635117. 

Mathew, R, Pujari-Palmer, M.; Guo, H.; Yu, Y.; Stevensson, B.; Engqvist, H.; Edén, M. Solid-State NMR Rationalizes the Bone-Adhesive Properties of Serine and Phosphoserine Bearing Calcium Phosphate Cements by Unveiling their Organic/Inorganic Interface. J. Phys. Chem. C, 2020, 124:39, 21512–21531. Doi: 10.1021/acs.jpcc.0c06224.

Wu, D., Palmer, M., Bojan, A., Palmquist, A., Procter, P., Öhman-Mägi, C., Ferguson, S., Isaksson, P., Persson, C. The effect of two types of resorbable augmentation materials–A cement and an adhesive-On the screw pullout resistance in human trabecular bone. Journal of the Mechanical Behavior of Biomedical Materials, 2020, 103897. Doi: 10.1016/j.jmbbm.2020.103897.

Pujari-Palmer, M., Giro, R., M. Insley, G., Procter, P., Engqvist, H. Factors That Determine the Adhesive Strength in a Bioinspired Bone Tissue Adhesive. ChemEngineering 2020, 4(1), 19; Doi: 10.3390/chemengineering4010019.

Spicer., C, Pujari-Palmer., M., Autefage, H., Bojan, A., Procter, P., Insley, G., Engqvist, H., Stevens, M. Synthesis of Phospho-Amino Acid Analogues as Tissue Adhesive Cement Additives. ACS Cent. Sci. 2020, 6:2, 226-231, Doi: 10.1021/acscentsci.9b01149.
Hulsart-Billström, G., Stelzl, C., Procter, P., Pujari-Palmer, M., Insley, G., Engqvist, H., Larsson, S. In vivo safety assessment of a bio-inspired bone adhesive. Journal of Materials Science: Materials in Medicine, 2020, 31:24. Doi: 10.1007/s10856-020-6362-3.

Lazraq Bystrom, J., Pujari-Palmer, M.* Phosphoserine Functionalized Cements Preserve Metastable Phases, and Reprecipitate Octacalcium Phosphate, Hydroxyapatite, Dicalcium Phosphate, and Amorphous Calcium Phosphate, during Degradation, In Vitro. J. Funct. Biomater. 2019, 10(4), 54; Doi: 0.3390/jfb10040054.

†Liu, X., †Pujari-Palmer, M., Wenner, D., Procter, P., Insley, G., Engqvist, H. Adhesive cements that bond soft tissue ex vivo. Materials 2019, 12 (15), 2473. Doi: 10.3390/ma12152473.

Procter, P.,  Pujari-Palmer, M., Hulsart-Billström, G., Wenner, D., Insley, G., Larsson, S., Engqvist, H. A biomechanical test model for evaluating osseous and osteochondral tissue adhesives. BMC Biomedical Engineering 2019, 1:11. Doi: 10.1186/s42490-019-0011-2.

Pujari-Palmer, M., Guo, H., Wenner, D., Autefage, H., Spicer, C., Stevens, M., Omar, O., Thomsen, P., Edén, M. Insley, G., Procter, P., Engqvist, H. A novel class of injectable bioceramics that glue tissues and biomaterials. Materials 2018, 11(12), 2492. Doi: 10.3390/ma11122492.

Fu, L., Xionga, Y., Carlsson, G., Palmer, M., Örnb, S., Zhu, W., Weng, X., Engqvist, H., Xia, W. Biodegradable Si3N4 bioceramic sintered with Sr, Mg and Si for spinal fusion: Surface characterization and biological evaluation. Applied Materials Today 2018 12; 260-275. Doi: 10.1016/j.apmt.2018.06.002.

Pujari-Palmer, M. The biological and physical performance of high strength dicalcium phosphate cement in physiologically relevant models. (Doctoral thesis)
http://www.diva-portal.org/smash/record.jsf?pid=diva2:1087377.

Pujari-Palmer M, Pujari-Palmer S, Lu X, Lind T, Melhus H, Engstrand T, Karlsson-Ott M, Engqvist H. Pyrophosphate Stimulates Differentiation, Matrix Gene Expression and Alkaline Phosphatase Activity in Osteoblasts. PLoS One. 2016 Oct 4;11 (10). Doi:10.1371/journal.pone.0163530.

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