CV-sida

Agneta Oskarsson

Professor emerita i livsmedelstoxikologi

Presentation

Professor i livsmedelstoxikologi sedan 1994. Tidigare chef för toxikologiska avdelningen på Livsmedelsverket, Director vid Reproductive Toxicity, Astra Zeneca R&D, forskare vid Institutet för miljömedicin, Karolinska institutet, mm. Mångårig erfarenhet av toxikologisk riskbedömning av miljöföroreningar, naturliga toxiner och livsmedelstillsatser, bland annat som expert vid Europeiska livsmedelsmyndigheten EFSA. 

Forskning

Kemiska hälsorisker i livsmedel och dricksvatten.

Utveckling och applicering av nya effektbaserade in vitro-metoder för detektion av kemiska hälsorisker.

Miljöanalys

Utveckling och applicering av effektbaserad analysmetodik för miljöövervakning.

Publikationer i urval

1.        Lundqvist, J., Hellman, B. and Oskarsson, A.: The fungicide prochloraz induces oxidative stress and DNA damage in vitro. Food Chem. Toxicol., 91, 36-41, 2016.

2.        Yagdiran, Y., Oskarsson, A., Knight, C.H. and Tallkvist, J.: ABC- and SLC- transporters in murine and bovine mammary epithelium – effects of prochloraz. PLOS ONE, 11(3):e0151904, 2016.

3.        Oskarsson, A. Ullerås, E. and Ohlsson Andersson, Å.: Acetaminophen increases aldosterone secretion while suppressing cortisol and androgens – a possible link to increased risk of hypertension. Am. J. Hypertens., 29, 1158-1164, 2016.

4.        Oskarsson, A. and Ohlsson Andersson, Å.: Suppressed sex hormone biosynthesis by alkylresorcinols – a possible link to chemoprevention. Nutrition and Cancer: An International Journal, 68, 978-987, 2016.

5.        Yagdiran, Y., Tallkvist, J., Artursson, K. and Oskarsson, A.: Staphylococcus aureus and lipopolysaccharide modulate gene expressions of drug transporters in mouse mammary epithelial cells – correlation to inflammatory biomarkers. PLOS ONE, 11(9): e0161346, 2016.

7.        Continuing Education Course 4: Evaluation of Food Additives in Europe: Point of the Art. Eurotox 2016, Sevilla, Spain, Toxicology Lett., 258 Suppl, S7, 2016.

8.        Oskarsson, A., Yagdiran, Y., Nazemi, S., Tallkvist, J. and Knight, C.H.: Short communication: Staphylococcus aureus infection modulates expression of drug transporters and inflammatory biomarkers in mouse mammary gland. J. Dairy Sci., 100, 2375-2380, 2017.

9.        Lundqvist, J., Pekar, H., and Oskarsson, A.: Short communication: Microcystins activate nuclear factor erythroid 2–related factor 2 (Nrf2) in human liver cells in vitro – Implications for an oxidative stress induction by microcystins. Toxicon, 126, 47-50, 2017.

10.     Lundqvist, J., Tringali, C and Oskarsson, A.: Resveratrol, piceatannol and analogs inhibit activation of both wild-type and T877A mutant androgen receptor. J Steroid Biochem. Mol. Biol., 174, 161-168, 2017. Highlighted in Nature Reviews Urology, Fenner, A., 14 (11) 2017, p 642.

11.      Oskarsson, A. as a member of the EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), 2017. Re-evaluation of potassium nitrite (E 249) and sodium nitrite (E 250) as food additives. EFSA Journal 2017;15(6):4786, 157 pp. doi:10.2903/j.efsa.2017.4786

 

12.     Oskarsson, A. as a member of the EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), 2017. Re-evaluation of sodium nitrate (E 251) as a food additive. EFSA Journal 2017;15(6):4787, 123 pp. doi:10.2903/j.efsa.2017.4787

13.     Rosenmai, A. K., Ahrens, L., Le Godec, T., Lundqvist, J. and Oskarsson, A.: Relationship between peroxisome proliferator-activated receptor alpha activity and cellular concentration of 14 perfluoroalkyl substances in HepG2 cells. J. Appl. Toxicol., 38, 219-226, 2018.

14.     Rosenmai, A.K., Niss, F., Mandava, G., Lundqvist, J. and Oskarsson, A.: Impact of natural organic matter in water on in vitro bioactivity assays. Chemosphere, 200, 209-216, 2018.

15.     Niss, F., Rosenmai, A.K., Mandava, G., Örn, S., Oskarsson, A. and Lundqvist, J.; Short communication: Toxicity bioassays with concentrated cell culture media - a methodology to overcome the chemical loss by conventional preparation of water samples. Environ. Sci. Pollut. Res., 25, 12183-12188, 2018.

16.     Rosenmai, A. K., Lundqvist, J., Le Godec, T., Ohlsson, Å., Tröger, R., Hellman, B. and Oskarsson, A.: In vitro bioanalysis of drinking water from source to tap. Water Res., 139, 272-280, 2018.

17.     Probert, P.M., Leitch, A.C., Dunn, M.P., Meyer, S.K., Palmer, J.M., Abdelghany, T.M., Lakey, A.F., Cooke, M.P., Talbot, H., Wills, C., McFarlane, W., Blake, L.I., Rosenmai, A.K., Oskarsson, A., Figueiredo, R., Wilson, C., Kass, G.E., Jones, D.E., Blain, P.G. and Wright, M.C.: Identification of a xenobiotic as a potential environmental trigger in primary biliary cholangitis. J. Hepatol., 69, 1123-1135, 2018. doi: 10.1016/j.jhep.2018.06.027

18.     Lungu-Mitea, S., Oskarsson, A. and Lundqvist, J.: Development of an oxidative stress in vitro assay in zebrafisk (Danio rerio) cell lines. Sci Rep., 2018 Aug 17;8 (1):12380. doi: 10.1038/s41598-018-30880-1.

19.     Rosenmai, A.K., Lundqvist, J., Gago-Ferrero, P., Mandava, G., Ahrens, L., Wiberg, K., and Oskarsson, A.: Effect-based assessment of recipient waters impacted by on-site, small scale, and large scale waste water treatment facilities – combining passive sampling with in vitro bioassays and chemical analysis. Scientific Reports, 2018 Nov 21; 8:17200. Doi:10.1038/s41598-018-35533-x

20. Oskarsson, A. as a member of the EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), 2018. Scientific opinion on the safety of green tea catechins. EFSA Journal 2018;16(4):5239, 89 pp. doi:10.2903/j.efsa.2018.5239

21.     Alexander, J. and Oskarsson, A.: Toxic metals. In Chemical Hazards in Food of Animal Origin. Food Safety Assurance and Veterinary Public Health No.7. F.J.M. Smulders, I.M.C.M. Rietjens and M.D. Rose, eds. Wageningen Academic Publishers, 2019, The Netherlands, pp 157-180.

22.     Lundqvist, J., Andersson, A., Johannisson, A., Lavonen, E., Mandava, G., Kylin, H., Bastviken, D. and Oskarsson, A.: Innovative drinking water treatment techniques reduce dissolved organic carbon (DOC) and the disinfection-induced oxidative stress and genotoxic activity. Water Res., 155, 182-192, 2019.

23.     Lundqvist, J., Helmersson, E. and Oskarsson, A.: Hormetic effect of NaAsO2 on proliferation of prostate cells in vitro – implications for prostate cancer initiation and therapy. Dose-Response, 17 (2), 1-6, 2019, doi: 10.1177/1559325819843374.

24.     Lundqvist, J., von Brömssen, C., Rosenmai, A.K., Ohlsson Å., Le Godec, T., Jonsson, O., Kreuger, J. and Oskarsson, A.: Assessment of pesticides in surface water samples from Swedish agricultural areas by integrated bioanalysis and chemical analysis. Environ. Sci. Eur., 31:53, 2019, doi.org/10.1186/s12302-019-0241-x. 

25.     Oskarsson, A. and Wright, M.C.: Ionic liquids: New emerging pollutants, similarities with perfluorinated alkyl substances (PFASs). Environ. Sci. Technol., 53, 10539-10541, 2019, doi: 10.1021/acs.est.9b04778.

26.     Oskarsson, A. as a member of the EFSA Panel on Food Additives and Flavourings (FAF), 2019. Scientific Opinion on Flavouring Group Evaluation 501 (FGE.501): Grill flavour concentrate (vegetable). EFSA Journal 2019;17(5):5675, 57 pp. doi:10.2903/j.efsa.2019.5675

27.     Leitch, A.C., Abdelghany, T.M., Probert, P.M., Dunn, M.P., Meyer, S.K., Palmer, J.M., Cooke, M.P., Blake, L.I., Morse, K., Rosenmai, A.K., Oskarsson, A., Bates, L., Figueiredo, R.S., Ibrahim, I., Wilson, C., Abdelkader, N.F., Jones, D.E., Blain, P.G. and Wright, M.C.: The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects. Food Chem. Toxicol., 136, 111069, 2020, doi: 10.1016/j.fct.2019.111069.


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